A method and apparatus for determination of a maximum number of uplink retransmissions in a wireless communication system is provided. A wireless device receives, from a network, information related to a first retransmission number for a first logical channel and second retransmission number for a second logical channel, determines a retransmission number of a data unit among the first retransmission number and the second retransmission number, and transmits, to the network, information for the retransmission number of the data unit.