- 专利标题: IMMUNOTHERAPEUTIC METHODS AND COMPOSITIONS
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申请号: US17415485申请日: 2019-12-19
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公开(公告)号: US20220062340A1公开(公告)日: 2022-03-03
- 发明人: Rimma GOLDBERG , Graham LORD
- 申请人: KING'S COLLEGE LONDON
- 申请人地址: GB London
- 专利权人: KING'S COLLEGE LONDON
- 当前专利权人: KING'S COLLEGE LONDON
- 当前专利权人地址: GB London
- 优先权: GB1820746.4 20181219,GB1900687.3 20190117
- 国际申请: PCT/GB2019/053618 WO 20191219
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; A61P37/06 ; A61P1/00 ; C12N5/0783
摘要:
This invention relates to immunotherapeutic methods involving administering immunoregulatory T cells (Tregs) with improved function to a subject. The invention also concerns modified Tregs having improved function and pharmaceutical compositions comprising the same. The improved Tregs of the invention have the capacity for increased gut-homing, amongst other improved functions. The methods and compositions of the invention are particularly useful in the treatment of immune-mediated gut disorders.