A supercritical CO2 boiler capable of realizing uniform combustion, corrosion resistance and coking resistance, and a boiler system are provided. The supercritical CO2 boiler includes a main combustion chamber, an upper furnace, a furnace arch and a flue, wherein a cross section of the main combustion chamber is circular or oval, or is of an N-sided shape, where N>4; at least four burner groups are disposed on the main combustion chamber, each group of burner nozzles corresponding to each burner group includes a recirculating air nozzle, a primary air nozzle and a secondary air nozzle; lateral recirculating air nozzles symmetrically distributed are respectively disposed at two sides of the primary air nozzle, the recirculating air nozzle and the lateral recirculating air nozzle are configured to feed recirculating flue gas or a mixed gas of the recirculating flue gas and secondary air into the main combustion chamber.