An image sensing device and an image sensing method are provided. The image sensing device includes a pixel array and a readout circuit. The pixel array includes multiple sensing sub-pixels arranged in an array. During a first exposure period of a frame period, the sensing sub-pixels are simultaneously exposed to respectively store multiple first sensing signals in multiple storage units of the sensing sub-pixels. During multiple first readout periods of the frame period, the readout circuit sequentially reads out the first sensing signals stored in the storage units during different periods. During each of multiple dynamic sensing periods of the frame period, all or part of the sensing sub-pixels are reset and then simultaneously exposed again, and the readout circuit then simultaneously reads out multiple second sensing signals of the sensing sub-pixels.