发明申请
- 专利标题: Method for Obtaining Low Molecular Weight Heparins by Tangential Flow Filtration
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申请号: US17509255申请日: 2021-10-25
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公开(公告)号: US20220112315A1公开(公告)日: 2022-04-14
- 发明人: Guillermo FRANCO RODRIGUEZ , Ibon GUTIERRO ADURIZ
- 申请人: LABORATORIOS FARMACEUTICOS ROVI, S.A.
- 申请人地址: ES MADRID
- 专利权人: LABORATORIOS FARMACEUTICOS ROVI, S.A.
- 当前专利权人: LABORATORIOS FARMACEUTICOS ROVI, S.A.
- 当前专利权人地址: ES MADRID
- 优先权: ESP201930373 20190426,CN202010078241.3 20200123
- 主分类号: C08B37/00
- IPC分类号: C08B37/00 ; B01D69/02 ; B01D61/14 ; B01D61/16
摘要:
Method for obtaining low molecular weight heparins (LMWH) with a weight average molecular weight distribution between 3.0 and 5.0 kDa comprising at least one concentration step by tangential flow filtration (TFF). The method is particularly useful for the preparation of bemiparin and enoxaparin without the use of fractional precipitation nor the use of alcoholic solutions. In particular, the preparation of LMWH is obtained by depolymerization of heparin and filtration (TFF ultrafiltration and/or diafiltration) of the depolymerized heparin without the use of fractional precipitation and without an alcoholic solution.
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