The present disclosure relates to systems, methods, and non-transitory computer-readable media for generating a response to a question received from a user during display or playback of a video segment by utilizing a query-response-neural network. The disclosed systems can extract a query vector from a question corresponding to the video segment using the query-response-neural network. The disclosed systems further generate context vectors representing both visual cues and transcript cues corresponding to the video segment using context encoders or other layers from the query-response-neural network. By utilizing additional layers from the query-response-neural network, the disclosed systems generate (i) a query-context vector based on the query vector and the context vectors, and (ii) candidate-response vectors representing candidate responses to the question from a domain-knowledge base or other source. To respond to a user's question, the disclosed systems further select a response from the candidate responses based on a comparison of the query-context vector and the candidate-response vectors.