Pulse amplitude modulation (PAM) encoding for a communication bus is disclosed. In particular, various two-wire communication buses may encode bits using three-level PAM (PAM-3) or five-level PAM (PAM-5) to increase bit transmission without requiring increases to clock frequencies or adding additional pins. Avoiding increases in clock frequencies helps reduce the risk of electromagnetic interference (EMI), and avoiding use of extra pins avoids cost increases for integrated circuits (ICs).