Various systems and methods for reactive intent-driven end-to-end (E2E) orchestration are described herein. An orchestrator system, includes a processor; and memory to store instructions, which when executed by the processor, cause the system to: receive, at the orchestrator system, an intent-based service level agreement (SLA) for execution of a series of tasks on a plurality of compute nodes; calculate, based on the intent-based SLA, intermediate latency thresholds corresponding to each task of the series of tasks; calculate slack estimates based on the latency thresholds and real-time telemetry of the plurality of compute nodes or real-time telemetry of connections between the plurality of compute nodes; monitor execution of the series of tasks on the plurality of compute nodes; and perform a corrective action in response to determining that the execution of the series of tasks is predicted to exceed one of the intermediate latency thresholds