The present disclosure provides a display substrate and a display panel, which belong to the field of display technologies. The display substrate includes: a base substrate; a signal line layer and a pixel electrode layer which are on one side of the base substrate and are insulated and spaced from each other. The signal line layer includes a plurality of signal lines, the pixel electrode layer includes a plurality of pixel electrodes arranged in an array. An orthographic projection of the pixel electrode to the base substrate overlaps an orthographic projection of at least one signal line to the base substrate. The technical solution of the present disclosure can improve the transmittance of the display device.