- 专利标题: CHIMERIC RECEPTOR THAT RECOGNIZES ENGINEERED SITE IN ANTIBODY
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申请号: US17603821申请日: 2020-04-17
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公开(公告)号: US20220143094A1公开(公告)日: 2022-05-12
- 发明人: Mika Sakurai , Tomoyuki Igawa , Koji Tamada , Yukimi Sakoda
- 申请人: Chugai Seiyaku Kabushiki Kaisha , Yamaguchi University
- 申请人地址: JP Tokyo; JP Yamaguchi
- 专利权人: Chugai Seiyaku Kabushiki Kaisha,Yamaguchi University
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha,Yamaguchi University
- 当前专利权人地址: JP Tokyo; JP Yamaguchi
- 优先权: JP2019-080566 20190419
- 国际申请: PCT/JP2020/016915 WO 20200417
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; C07K16/28 ; C12N15/63
摘要:
The present disclosure provides a pharmaceutical composition for use in combination with administration of a mutated antibody having a mutation, including substitution, deletion, addition or modification, of at least one amino acid in a CH1 region, a CH2 region, a CH3 region, a CL region, or a framework region, wherein the pharmaceutical composition comprises a cell expressing a chimeric receptor, the mutated antibody is capable of binding to the extracellular binding domain of the chimeric receptor via a moiety having the mutation, and the extracellular binding domain does not bind to an antibody free of the mutation.
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