Systems, devices, and methods related to a Deep Learning Accelerator and memory are described. For example, an integrated circuit device may be configured to execute instructions with matrix operands and configured with random access memory. A compiler can convert a description of an artificial neural network into a compiler output through optimization and/or selection of hardware options of the integrated circuit device. The compiler output can include parameters of the artificial neural network, instructions executable by processing units of the Deep Learning Accelerator to generate an output of the artificial neural network responsive to an input to the artificial neural network, and hardware options to be stored in registers connected to control hardware configurations of the processing units.