A method of driving a display panel includes dividing an input image into a plurality of segments, generating a flicker value of a segment of the plurality of segments, determining whether to compensate the flicker value of the segment or not according to a segment size, compensating the flicker value of the segment based on the segment size, determining a frame rate of the display panel based on the flicker value of the segment and outputting a data voltage to the display panel in the frame rate. The flicker value of the segment is compensated based on the flicker value of the segment and flicker values of segments that are adjacent to the segment.