There is provided a work machine that can limit operation of a work device by MC, and improves the responsiveness of a hydraulic actuator to operation of an operation device by an operator, and ensures operability equivalent to that of a work machine that does not have MC functions, and allows the hydraulic actuator for which the operation device is not being operated to automatically operate in either direction of the operation directions thereof. For this purpose, a drive system includes a selector valve 203a disposed between a secondary port 134a of an operation device 45a and a flow control valve 15a and between a proportional solenoid valve 54a and the flow control valve 15a and a selector valve 203b disposed between a secondary port 134b of the operation device 45a and the flow control valve 15a and between a proportional solenoid valve 54b and the flow control valve 15a. A controller 40 switches the selector valves 203a and 203b to either one of a first position and a second position on the basis of signals from pressure sensors 70a and 70b and pressure sensors 200a and 200b and target operation set in advance regarding the selector valves 203a and 203b.