A method and apparatus for loop problem handling of conditional mobility, e.g., conditional handover (CHO) is provided. A wireless device configured to operate in a wireless communication system receives, from a network node serving the source cell, a mobility command for conditional mobility. The mobility command includes 1) target cell configurations associated to one or more target cells, and 2) information informing that it is allowed to perform the conditional mobility up to a maximum number of trials for the conditional mobility upon detecting a failure. The wireless device selects a cell from among the one or more target cells upon detecting the failure, and performs the conditional mobility by applying a target cell configuration associated to the selected cell, from among the target cell configurations included in the mobility command, based on the information included in the mobility command.