Invention Application
- Patent Title: SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS
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Application No.: US17431006Application Date: 2020-02-14
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Publication No.: US20220162201A1Publication Date: 2022-05-26
- Inventor: Dean A. Wacker , Susheel Jethanand Nara , Srinivas Cheruku , Kandhasamy Sarkunam , Firoz Ali Jaipuri , Rishikesh Narayan , Subba Reddy Bandreddy , Srinivas Jogi
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- International Application: PCT/US2020/018210 WO 20200214
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D403/12 ; C07D217/06 ; C07D271/06 ; C07D417/14

Abstract:
Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein Q is C2-6 alkenyl or C2-6 alkynyl, each substituted with zero to 2 R1; and the other variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
Public/Granted literature
- US12227496B2 Substituted bicyclic compounds as farnesoid X receptor modulators Public/Granted day:2025-02-18
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