Invention Application
- Patent Title: SMALL MOLECULES FOR CANCER THERAPY THAT REDUCE THE EXPRESSION OF TRANSCRIPTION FACTORS KLF5 AND EGR-1
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Application No.: US17602924Application Date: 2020-04-10
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Publication No.: US20220177425A1Publication Date: 2022-06-09
- Inventor: Thomas D. Bannister , Chao Wang , Agnieszka Bialkowska , Vincent Yang
- Applicant: THE SCRIPPS RESEARCH INSTITUTE , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
- Applicant Address: US CA La Jolla; US NY Albany
- Assignee: THE SCRIPPS RESEARCH INSTITUTE,THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
- Current Assignee: THE SCRIPPS RESEARCH INSTITUTE,THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
- Current Assignee Address: US CA La Jolla; US NY Albany
- International Application: PCT/US20/27716 WO 20200410
- Main IPC: C07D207/09
- IPC: C07D207/09 ; A61P35/00 ; C07D207/48 ; C07D295/26 ; C07D243/08 ; C07D211/28 ; C07D211/96
Abstract:
The present disclosure provides compounds of formula (I), as described herein, their pharmaceutically acceptable salts, and their pharmaceutical compositions, which are effective in reducing the expression level of KLF5 or EGR1 in a living cell, and for the treatment of tumors and colorectal cancer in a human patient.
Information query
