The invention discloses a spatial and temporal feature-based method for measuring domestic wastewater effluent loadings, comprising the following steps: establish a model for measuring regional domestic wastewater effluent loadings; calculate regional population distribution raster data; obtain per capita effluent loading coefficients with spatial and temporal differences; calculate regional domestic wastewater effluent loadings; and compare and analyze the temporal fluctuation features and spatial variation features of regional domestic wastewater effluent loadings and identify “hotspot” periods and areas of effluent loadings. Compared with the prior art, the method for measuring domestic wastewater effluent loadings provided by the present invention is flexible, convenient and highly universal, which can significantly raise the temporal-spatial resolution of the pattern of regional domestic wastewater effluent loadings. The data needed are also publicly available. This invention can help identify key pollution areas and periods and lay a methodological foundation for precision pollution control.