A method of generating a font database, and a method of training a neural network model are provided, which relate to a field of artificial intelligence, in particular to a computer vision and deep learning technology. The method of generating the font database includes: determining, by using a trained similarity comparison model, a basic font database most similar to handwriting font data of a target user in a plurality of basic font databases as a candidate font database; and adjusting, by using a trained basic font database model for generating the candidate font database, the handwriting font data of the target user, so as to obtain a target font database for the target user.