Invention Application
- Patent Title: INTRANASAL DELIVERY OF OLANZAPINE BY PRECISION OLFACTORY DEVICE
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Application No.: US17574511Application Date: 2022-01-12
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Publication No.: US20220183965A1Publication Date: 2022-06-16
- Inventor: John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das
- Applicant: Impel Neuropharma, Inc.
- Applicant Address: US WA Seattle
- Assignee: Impel Neuropharma, Inc.
- Current Assignee: Impel Neuropharma, Inc.
- Current Assignee Address: US WA Seattle
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/5513 ; A61M15/00 ; A61K9/16 ; A61P25/18 ; A61K31/00

Abstract:
Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (Cmax) of at least 30 ng/mL, with (b) a mean time to Cmax (Tmax) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.
Public/Granted literature
- US11752100B2 Intranasal delivery of olanzapine by precision olfactory device Public/Granted day:2023-09-12
Information query