Invention Application
![PYRIMIDO[5,4-B]PYRROLIZIN COMPOUND, OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF](/docs/US/2022-06-30/US20220204518A1/abs.jpg.600x600.jpg)
- Patent Title: PYRIMIDO[5,4-B]PYRROLIZIN COMPOUND, OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
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Application No.: US17606121Application Date: 2020-04-24
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Publication No.: US20220204518A1Publication Date: 2022-06-30
- Inventor: Ao ZHANG , Jian DING , Hua XIE , Zilan SONG , Yu XUE , Li XING , Linjiang TONG , Meiyu GENG
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Priority: CN201910334619.9 20190424
- International Application: PCT/CN2020/086787 WO 20200424
- Main IPC: C07D487/14
- IPC: C07D487/14 ; A61P35/00
![PYRIMIDO[5,4-B]PYRROLIZIN COMPOUND, OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF](/abs-image/US/2022/06/30/US20220204518A1/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.
Information query
