Invention Application
- Patent Title: METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY
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Application No.: US17499284Application Date: 2021-10-12
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Publication No.: US20220205046A1Publication Date: 2022-06-30
- Inventor: Victor Abkevich , Alexander Gutin , Kirsten Timms , Jerry Lanchbury
- Applicant: Myriad Genetics, Inc.
- Applicant Address: US UT Salt Lake City
- Assignee: Myriad Genetics, Inc.
- Current Assignee: Myriad Genetics, Inc.
- Current Assignee Address: US UT Salt Lake City
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; C12Q1/6827 ; G16B20/00 ; G16H20/00 ; G16B20/20 ; G16B20/10

Abstract:
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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