Provided are a medical care support device, an operation method and a non-transitory computer readable recording medium storing an operation program thereof, and a medical care support system capable of promptly proposing necessary examinations and treatments in a case where a patient suffers from a chronic disease. A medical care support device (12) includes a display screen generation unit (62) and a prediction execution unit (63). The prediction execution unit (63) extracts a specific disease affecting a patient from acquired medical care information, and outputs a chronic disease and a complication that is likely to occur with a morbidity of the chronic disease as a prediction result. The display screen generation unit (62) proposes medical care practices for both the chronic disease and the complication.