A method for dynamic calibration correction in multi-frame, multi-exposure capture in a camera system includes receiving an amplified non-reference frame (e.g., with non-standard exposure value EV-4) to which a digital gain was applied and a reference frame (e.g., with standard exposure value EV0). The method includes generating a mask based on the reference frame and the amplified non-reference frame. The method includes estimating a scaling coefficient and an offset coefficient for each of a number of channels in the amplified non-reference frame, based on selected pixel locations in the generated mask. The method includes correcting a calibration of the amplified non-reference frame by applying the scaling coefficients for each of the channels. The method also includes outputting a calibration-corrected amplified non-reference frame to a multi-frame processor.