- 专利标题： ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS
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申请号： US17257792申请日： 2019-07-02
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公开(公告)号： US20220228184A1公开(公告)日： 2022-07-21
- 发明人: Mark A. Huffman , Anna Fryszkowska , Joshua N. Kolev , Paul N. Devine , Kevin R. Campos , Matthew Truppo , Christopher C. Nawrat
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2019/040316 WO 20190702
- 主分类号： C12P19/40
- IPC分类号： C12P19/40 ; C12P17/04 ; C12P9/00 ; C12P7/18 ; C07H13/00 ; C07F9/113 ; C07C33/042
摘要：
The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.
公开/授权文献
- US12037623B2 Enzymatic synthesis of 4′-ethynyl nucleoside analogs 公开/授权日：2024-07-16
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