Described embodiments provide systems and methods for stream-based compression. An encoder of a first device receives an input stream of bytes including a first byte preceded by one or more second bytes. The encoder may determine to identify a prefix code for the first byte. The encoder may select a prefix code table using the one or more second bytes. The encoder may identify, from the selected prefix code table, the prefix code of the first byte. The encoder may generate an output stream of bytes by replacing the first byte in the input stream with the prefix code of the first byte. The encoder may transmit the output stream from the encoder of the first device to a decoder of a second device. The output stream may have a fewer number of bits than the input stream.