Provided is a trolley bag with separated middle frame structure and hinge and having shock-absorbing structure, which includes a trolley handle, a rear case, a middle frame, and a front case. The middle frame structure includes a hinge structure and a pair of middle frames. One of the pair of middle frames is connected to the rear case, and the other one is connected to the front case. The hinge structure includes a pair of hinges and a core pin, one of the pair of hinges is connected to one of the middle frames, the other is connected to the other one of the middle frames. The pair of hinges are movably connected through the core pin. The pair of middle frames is locked together by an interlocking assembly. Shock-absorbing wheels are arranged at four corners of a bottom of the trolley bag.