The present disclosure relates to an apparatus and method for compensating for pixel data, a display panel and a storage medium. In one or more embodiments, the method includes: obtaining a first display area and a second display area of the display panel; obtaining, by mapping respective initial pixel data of pixels in the first display area using a preset grayscale target value, respective intermediate pixel data of the pixels in the first display area; and obtaining, by compensating for respective initial pixel data of pixels in the second display area and the respective intermediate pixel data of the pixels in the first display area using preset compensation coefficients, respective target pixel data of pixels in the second display area and the first display area.