There is described a method of assessing a phenotype of a biological tissue of a patient. The method generally having receiving a Raman emission signal indicative of Raman emission of a portion of said biological tissue; using a feature generator, determining a value of a first feature based on said received Raman emission signal; using a computing device, receiving a value of a clinical parameter associated to the patient; generating a value of a second feature by interacting said value of said first feature with said value of said clinical parameter; using a trained assessment engine, assessing the phenotype of the biological tissue based on at least said value of said second feature; and outputting a signal based on said assessment.