Systems, methods, and apparatuses for pre-configured per-tenant isolation in a multi-tenant cloud based computing environment. An exemplary system having a processor and a memory therein includes means for creating an isolation group, in which creating the isolation groups includes: defining isolation requirements, identifying a group of features utilizing call-out functions, and selecting from among the group of features utilizing call-out functions a group of features having the defined isolation requirements; deploying platform software integrating the isolation requirements, in which the platform software contains instructions to map the isolation requirements to a customer organization; creating the customer organization; creating a unique variant of the customer organization, in which creating the unique variant of the customer organization includes declaratively applying an isolation layer containing isolation requirements on top of a base layer for the customer organization; and deploying the unique variant of the customer organization onto the customer organization's computing infrastructure, in which the unique variant validates per-tenant distinctions for various applications subjected to the isolation requirements.