Dressings, systems, and methods for treating a tissue site are described herein. The dressing has a contact layer having a plurality of holes. The contact layer is configured to be positioned adjacent to the tissue site. The dressing also includes a cover layer having a first side configured to be positioned adjacent to the contact layer and a second side opposite the first side. An antimicrobial agent is coupled to the first side of the cover layer. The dressing has a drape configured to be positioned over the cover layer to form a sealed space having the contact layer and the cover layer disposed in the sealed space.