Invention Application
- Patent Title: METHODS OF IDENTIFYING DOPAMINERGIC NEURONS AND PROGENITOR CELLS
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Application No.: US17629766Application Date: 2020-07-24
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Publication No.: US20220254448A1Publication Date: 2022-08-11
- Inventor: Jeanne F. LORING , Franz-Josef MÜLLER , Roy WILLIAMS , Bernhard M. SCHULDT , Andres BRATT-LEAL
- Applicant: Franz-Josef MÜLLER , Bernhard M. SCHULDT , The Scripps Research Institute , Aspen Neuroscience, Inc.
- Applicant Address: DE Felde; DE Düsseldorf; US CA La Jolla; US CA San Diego
- Assignee: Franz-Josef MÜLLER,Bernhard M. SCHULDT,The Scripps Research Institute,Aspen Neuroscience, Inc.
- Current Assignee: Franz-Josef MÜLLER,Bernhard M. SCHULDT,The Scripps Research Institute,Aspen Neuroscience, Inc.
- Current Assignee Address: DE Felde; DE Düsseldorf; US CA La Jolla; US CA San Diego
- International Application: PCT/US2020/043627 WO 20200724
- Main IPC: G16B25/10
- IPC: G16B25/10 ; G16B40/20 ; C12N5/0793 ; A61K35/30

Abstract:
Provided herein are, inter alia, methods of assaying neuronal progenitor cell populations derived from iPSCs, thereby providing for a user friendly molecular diagnostic tool for neuronal cell types, including dopaminergic neurons. The methods provided are valuable for the efficient and precise characterization of identity and functionality of iPSC-derived dopaminergic neurons prior to their clinical application such as the treatment of Parkinson's disease or Multiple Sclerosis.
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