Embodiments of the present disclosure are directed to a radio frequency (RF) parameter processing method, a related device, a mobile terminal and a storage medium. The RF parameter processing method includes obtaining an RF parameter, performing a calibration process on the RF parameter to obtain a target RF parameter, wherein the target RF parameter comprises a target dynamic RF parameter, backing up the target dynamic RF parameter into a predetermined partition, and upon detecting a setting information, injecting the target dynamic RF parameter stored in the predetermined partition into an activated partition.