A plugged honeycomb structure includes a honeycomb structure body having a porous partition wall disposed to surround a plurality of cells; and a plugging portion disposed at one end of the cells, wherein, in a section orthogonal to the extending direction of the cell, the cells each have a shape that is polygon, and one of the inflow cells and another are adjacent to each other with the partition wall therebetween, and in the section orthogonal to the extending direction of the cell, a total area of the inflow cell is larger than a total area of the outflow cell, a porosity of the partition wall is 38% or more, a thickness of the partition wall is 125 μm or more and 280 μm or less, a cell density of the honeycomb structure body is 31.0 cells/cm2 or more, and an air-permeability resistance of the partition wall is 4.5×107Pa·s/m2 or less.