A computer sound card includes a power supply noise isolation circuit for reducing ground plane noise generated during application of heavy electrical loads to the power supply, such as loads presented by computer GPUs. The power supply isolation circuit isolates the output ground from the ground presented from the power supply to the isolation circuit input. The isolation circuit in one embodiment includes switching circuitry and a transformer to reduce the power supply ripple noise that might otherwise be introduced by the power supply into an amplifier such as a microphone preamp. In some embodiments a differential amplifier stage is added to the output of the microphone preamp stage to further reduce noise, such as common mode noise.