This disclosure relates to methods and devices for configuring guard subcarriers in transmission subbands to reduce interband interference in a wireless communication network. In one implementation, the method may include determining that a first subcarrier spacing for a first radio frequency transmission band is less than a second subcarrier spacing for a second radio frequency transmission band, and the first radio frequency transmission band is close to the second radio frequency transmission band in frequency spectrum. The method may further include configuring a subcarrier of the first radio frequency transmission band as a guard subcarrier carrying dummy data when the first radio frequency transmission band and the second radio frequency transmission band are simultaneously used to transmit data loads.