A resource scheduling method and apparatus, a device, and a storage medium are provided, and relates to the field of computer technology, and in particular to the field of deep learning technology. The method includes: acquiring a graphics processing unit (GPU) topology relationship of a cluster according to GPU connection information of each of computing nodes in the cluster; and in a case where a task request, for applying for a GPU resource, for a target task is received, determining a target computing node of the target task and a target GPU in the target computing node according to the task request and the GPU topology relationship, to complete GPU resource scheduling of the target task. The present disclosure can optimize the resource scheduling.