The present disclosure relates to bioreactor tiles including fluidic channels and optical waveguides. One example system includes a substrate having a first channel, a second channel, and a third channel defined therein. The three channels are separated from one another by partial wall structures. The system also includes an optical waveguide configured to receive illumination light at a first end of the optical waveguide; propagate the illumination light toward a second end of the optical waveguide; allow at least a portion of the illumination light to escape the optical waveguide from a first surface of the optical waveguide as the illumination light propagates toward the second end of the optical waveguide; and provide the portion of the illumination light that escapes the optical waveguide from the first surface to the second channel or the third channel.