Given the complexity of architectural spaces and the need to calculate spherical irradiances, it is difficult to determine how much ultraviolet radiation is necessary to adequately kill airborne pathogens. An interior environment with luminaires is modeled. Spherical irradiance meters are positioned in the model and the direct and indirect spherical irradiance is calculated for each sensor. From this, an irradiance field is interpolated for a volume of interest, and using known fluence response values for killing pathogens, a reduction in the pathogens is predicted. Based on the predicted reduction, spaces are built accordingly, and ultraviolet luminaires are installed and controlled.