Invention Application
- Patent Title: STERIC EPITOPE OF CEACAM1, AND ANTI-CEACAM1 ANTIBODY, OR FRAGMENT THEREOF, THAT SPECIFICALLY BINDS TO SAME
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Application No.: US17770500Application Date: 2019-11-07
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Publication No.: US20220289819A1Publication Date: 2022-09-15
- Inventor: Mi-Young OH , Jae-Chul LEE , Hye Young PARK , Hye In YUM , Dong-Sik KIM
- Applicant: GREEN CROSS CORPORATION , MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Applicant Address: KR Yongin, Gyeonggi-do; KR Yongin-si, Gyeonggi-do
- Assignee: GREEN CROSS CORPORATION,MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee: GREEN CROSS CORPORATION,MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee Address: KR Yongin, Gyeonggi-do; KR Yongin-si, Gyeonggi-do
- International Application: PCT/KR2019/015080 WO 20191107
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K16/28 ; A61P35/00
Abstract:
A steric epitope of CEACAM1 is disclosed. An anti-CEACAM1 antibody or a fragment thereof, which specifically binds to CEACAM1 is disclosed. A steric epitope of CEACAM1 includes all amino acids in critical positions for specific binding to an anti-CEACAM1 antibody and maintains an appropriate three-dimensional structure, and thus can high affinity for an anti-CEACAM1 antibody. In addition, an antibody, or a fragment thereof, that specifically binds to a steric epitope can effectively suppress CEACAM1-CEACAM1 interaction and CEACAM1-CEACAM6 interaction.
Information query
