A context sensitive guidance (CSG) system for providing clinical interventions to a patient in an emergency medical event includes a CSG engine, patient interface devices configured to generate signals indicative of patient physiologic data, and a display device configured to provide a CSG user interface and medical device(s) configured to couple to the patient interface devices, the CSG engine and the display device, receive the signals, generate the physiologic data from the signals, and send the physiologic data to the CSG engine and the display device, wherein the CSG engine is configured to receive and evaluate the physiologic data, identify a clinical intervention, and send an output based on the clinical intervention to the medical device(s) configured to perform at least one operation in response to the sent output.