- 专利标题： B CELL TARGETED PARALLEL CAR (pCAR) THERAPEUTIC AGENTS
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申请号： US17638742申请日： 2020-08-28
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公开(公告)号： US20220298223A1公开(公告)日： 2022-09-22
- 发明人: John MAHER , Leena HALIM
- 申请人： KING'S COLLEGE LONDON
- 申请人地址： GB London
- 专利权人： KING'S COLLEGE LONDON
- 当前专利权人： KING'S COLLEGE LONDON
- 当前专利权人地址： GB London
- 国际申请： PCT/EP2020/074071 WO 20200828
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C07K16/28
摘要：
Provided herein are immuno-responsive cells expressing a B cell targeting pCAR comprising a 2nd generation chimeric antigen receptor (CAR) and a chimeric co-stimulatory receptor (CCR). Also provided herein are methods of preparing the immuno-responsive cells and methods of directing T cell mediated immune response using the immuno-responsive cells.
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