A dryer appliance and a method of operating the same are provided. In one aspect, the dryer appliance includes a drum rotatably mounted within a cabinet. The drum defines a chamber that is in fluid communication with a conditioning system of the dryer appliance that circulates heated air through the chamber. A controller is configured to receive a command to initiate an appliance travel cycle and implement a responsive action to prepare the dryer appliance for travel. The responsive action may be the automated adjustment of one or more operating parameters of the dryer appliance, such as performing a load sensing procedure, drying the chamber, closing the water supply valves, etc. In addition, the responsive action may include providing a user instruction to prepare the dryer appliance, e.g., by cleaning the lint filter, emptying the condensate collection tank, removing hoses and cables, addressing any error codes, etc.