发明申请
- 专利标题： DRUG-POLYMER AMORPHOUS SOLID DISPERSIONS USING LINEAR POLY(ACRYLIC ACID) POLYMERS
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申请号： US17635815申请日： 2020-08-28
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公开(公告)号： US20220304936A1公开(公告)日： 2022-09-29
- 发明人: Elena S. Draganoiu , Barbara J. Morgan , David W. Weaver , Shreya P. Shah , Todd J. Wilson , Michael Grieco , Cynthia S. Randall , Kimberly A. Zubris , Mark A. Mitchnick , Liliana A. Miinea
- 申请人： LUBRIZOL ADVANCED MATERIALS, INC.
- 申请人地址： US OH Cleveland
- 专利权人： LUBRIZOL ADVANCED MATERIALS, INC.
- 当前专利权人： LUBRIZOL ADVANCED MATERIALS, INC.
- 当前专利权人地址： US OH Cleveland
- 国际申请： PCT/US2020/048429 WO 20200828
- 主分类号： A61K9/20
- IPC分类号： A61K9/20 ; A61K31/427 ; A61K31/496
摘要：
An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an active pharmaceutical ingredient includes forming a liquid dispersion of a linear poly(acrylic acid), an active pharmaceutical ingredient, and a solvent system, the linear poly(acrylic acid) having a Brookfield viscosity at 25° C. of at least 100 cP and evaporating the solvent system from the liquid dispersion to form an amorphous solid dispersion.
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