The present invention relates to a CFD numerical simulation based fluid equipment resistance optimization algorithm, including the following steps: establishing a fluid equipment unit library; establishing CFD models of fluid equipment units in the fluid equipment unit library, and obtaining a correspondence between a flow rate and a resistance of each fluid equipment unit based on a CFD model of the fluid equipment unit; obtaining fluid equipment units that constitute to-be-tested fluid equipment, and a quantity and a connection sequence of the fluid equipment units; calculating a resistance of each fluid equipment unit based on a flow rate and a correspondence between the flow rate and the resistance of each fluid equipment unit; and adding up resistances of the fluid equipment units in the to-be-tested fluid equipment based on their connection sequence, to obtain a resistance of the to-be-tested fluid equipment.