- 专利标题： CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS
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申请号： US17835311申请日： 2022-06-08
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公开(公告)号： US20220313837A1公开(公告)日： 2022-10-06
- 发明人: Yongxin Robert ZHAO , Qingliang YANG , Yuanyuan HUANG , Shun GAI , Hangbo YE , Linyao ZHAO , Chengyu YANG , Huihui GUO , Xiaomai ZHOU , Hongsheng XIE , Haifeng ZHU , Yifang XU , Qianqian TONG , Junxiang JIA , Minjun CAO , Wenjun LI , Shuihong GAO , Zhixiang GUO , Lu BAI , Chen LI , Yanlei YANG , Chunyan WANG , Zhichang YE
- 申请人： Hangzhou DAC Biotech Co., Ltd.
- 申请人地址： CN Hangzhou
- 专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人地址： CN Hangzhou
- 主分类号： A61K47/68
- IPC分类号： A61K47/68
摘要：
The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
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