- 专利标题： APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
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申请号： US17518249申请日： 2021-11-03
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公开(公告)号： US20220315555A1公开(公告)日： 2022-10-06
- 发明人: Milan BRUNCKO , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa A. HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Xiaohong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , Robert MANTEI , Todd M. HANSEN
- 申请人： AbbVie Inc. , Genentech, Inc. , The Walter and Eliza Hall Institute of Medical Research
- 申请人地址： US IL North Chicago; US CA South San Francisco; AU Parkville
- 专利权人： AbbVie Inc.,Genentech, Inc.,The Walter and Eliza Hall Institute of Medical Research
- 当前专利权人： AbbVie Inc.,Genentech, Inc.,The Walter and Eliza Hall Institute of Medical Research
- 当前专利权人地址： US IL North Chicago; US CA South San Francisco; AU Parkville
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D519/00 ; C07D471/04 ; C07D209/82 ; C07D403/12 ; A61K31/496
摘要：
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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