A display substrate and a display device. In the display substrate, at least one of the inter-opening region, the first opening peripheral region and the second opening peripheral region includes a first virtual sub-pixel; the first signal line extends along a first direction and includes a first portion passing through the first opening peripheral region, the inter-opening region and the second opening peripheral region; the first portion passes through the first virtual sub-pixel, and the first virtual sub-pixel includes a first compensation capacitor, a first plate of the first compensation capacitor is in a same layer as the first portion of the first signal line and electrically connected with the first portion of the first signal line, and in a same layer as the second plate of the storage capacitor; the second plate is in a different layer from, insulated from, and overlaps with the first plate.