- 专利标题: ANTIBODY CLEAVAGE SITE BINDING MOLECULE
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申请号: US17615748申请日: 2020-06-05
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公开(公告)号: US20220324975A1公开(公告)日: 2022-10-13
- 发明人: Mika Sakurai , Tomoyuki Igawa , Yasunori Komori , Koji Tamada , Yukimi Sakoda
- 申请人: Chugai Seiyaku Kabushiki Kaisha , Yamaguchi University
- 申请人地址: JP Tokyo; JP Yamaguchi
- 专利权人: Chugai Seiyaku Kabushiki Kaisha,Yamaguchi University
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha,Yamaguchi University
- 当前专利权人地址: JP Tokyo; JP Yamaguchi
- 优先权: JP2019-105761 20190605
- 国际申请: PCT/JP2020/022218 WO 20200605
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; A61K35/17
摘要:
The present disclosure provides a pharmaceutical composition comprising an antibody having ADCC activity, a T cell-redirecting antibody, or a cell expressing a chimeric receptor, for use in combination with the administration of an antigen binding molecule capable of binding to a target antigen, wherein the primary molecule comprises a linker that is cleaved by protease, the antigen binding molecule obtained through the cleavage of the linker has the ability to bind to the target antigen, variable regions of the antibody having ADCC activity or the T cell-redirecting antibody, and an extracellular binding domain of the chimeric receptor bind to a cell expressing the target antigen via binding to the antigen binding molecule resulting from the cleavage of the cleavable linker.
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