Systems and methods for monitoring a network slice are provided. A method, according to one implementation, include extracting information from network traffic received from one or more User Plane Function (UPF) components of a network slice; examining the extracted information using Machine Learning (ML), and, in response to detecting of one or more malicious threats based on the examined extracted information by the ML, causing one or more actions to isolate the network traffic to protect at least the network slice from the one or more malicious threats.