Invention Application
- Patent Title: T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS
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Application No.: US17810238Application Date: 2022-06-30
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Publication No.: US20220331364A1Publication Date: 2022-10-20
- Inventor: Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
- Applicant: Triumvira Immunologics USA, Inc. , McMaster University
- Applicant Address: US TX Austin; CA Hamilton
- Assignee: Triumvira Immunologics USA, Inc.,McMaster University
- Current Assignee: Triumvira Immunologics USA, Inc.,McMaster University
- Current Assignee Address: US TX Austin; CA Hamilton
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K14/725 ; A61P35/00 ; C07K14/82

Abstract:
A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
Information query
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